Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 5/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29613142 | 0.76 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL19252773 | 0.76 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL19259465 | 0.76 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL14590599 | 0.74 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL19252795 | 0.74 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL19272921 | 0.74 | HIF1A (0.36) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL18423334 | 0.72 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL29613148 | 0.72 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL29613183 | 0.71 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL19252770 | 0.71 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416946-A1 | TETRACYCLIC PYRIDONE COMPOUNDS AS ANTIVIRALS | Novartis AG (CH) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017140821-A1 | TETRACYCLIC PYRIDONE COMPOUNDS AS ANTIVIRALS | NOVARTIS AG (CH) | 2017-08-24 | — | — | WO | disclosed |