Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11939279 | 0.79 | ALDH1A1 (0.38) | ALDH1A1MAPK1CYP3A4CYP2C9NPC1 | |
| SCHEMBL2176010 | 0.79 | POLB (0.46) | ALDH1A1CYP3A4NPC1RAB9AHTT | |
| SCHEMBL6336580 | 0.78 | CCNB2 (0.46) | ALDH1A1MAPK1CYP3A4CYP2C9NPC1 | |
| SCHEMBL1011188 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MAPK1CYP3A4CYP2C9NPC1 | |
| SCHEMBL13788817 | 0.70 | PTPN1 (0.42) | ALDH1A1MAPK1CYP3A4CYP2C9NPC1 | |
| SCHEMBL19334551 | 0.68 | KDM4E (0.47) | ALDH1A1MAPK1CYP3A4CYP2C9NPC1 | |
| SCHEMBL3786178 | 0.67 | MAPT (0.44) | ALDH1A1MAPK1NPC1RAB9AMAPT | |
| SCHEMBL186301 | 0.67 | RAB9A (0.37) | ALDH1A1MAPK1NPC1RAB9AMAPT | |
| SCHEMBL23456183 | 0.67 | MAPT (0.43) | ALDH1A1MAPK1CYP3A4CYP2C9NPC1 | |
| SCHEMBL11932877 | 0.67 | MEN1 (0.38) | ALDH1A1MAPK1CYP3A4CYP2C9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416633-B1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | UNIV ILLINOIS (US) | 2025-07-23 | — | — | EP | disclosed |
| US-10456394-B2 | Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2019-10-29 | — | — | US | disclosed |
| US-10456394-B2 | Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2019-10-29 | — | — | US | disclosed |
| US-20190255046-A1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOS (US) | 2019-08-22 | — | — | US | disclosed |
| US-20190255046-A1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOS (US) | 2019-08-22 | — | — | US | disclosed |
| EP-3416633-A1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | The Board of Trustees of the University of Illinois (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142883-A1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017142883-A1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190255046-A1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | HDAC1, HDAC5, HDAC7 | ALDH1A1 1708/4885MAPK1 3221/4885CYP3A4 4388/4885 |
| US-10456394-B2 | Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors | HDAC1, HDAC5, HDAC7 | ALDH1A1 1708/4885MAPK1 3221/4885CYP3A4 4388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.