Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 13/20 | 0.50 |
| ▸ | ACACB | O00763 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926573 | 0.79 | GRM2 (0.48) | GRM2ACACBOPRM1 | |
| SCHEMBL6928779 | 0.77 | GRM2 (0.43) | GRM2ACACBOPRM1 | |
| SCHEMBL19625664 | 0.76 | OPRM1 (0.44) | GRM2OPRM1 | |
| SCHEMBL746720 | 0.74 | DHFR (0.48) | GRM2 | |
| SCHEMBL746858 | 0.70 | GRM2 (0.51) | GRM2 | |
| SCHEMBL17557415 | 0.69 | GRM2 (0.49) | GRM2ACACBOPRM1 | |
| SCHEMBL16944207 | 0.67 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17557414 | 0.67 | GRM2 (0.45) | GRM2ACACBOPRM1 | |
| SCHEMBL27849033 | 0.66 | GRM2 (0.45) | GRM2 | |
| SCHEMBL10819324 | 0.66 | DHFR (0.48) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9737533-B2 | 1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of prevention of neurological and psychiatric disorders | Janssen Pharmaceuticals. Inc. (US) | 2017-08-22 | — | — | US | disclosed |