Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 12/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25975747 | 0.88 | KMT2A (0.46) | SPRL3MBTL1PDE5AKMT2ASLC22A12 | |
| SCHEMBL15937474 | 0.83 | PDE5A (0.34) | PDE5AGRIN1GRIN2B | |
| SCHEMBL19264503 | 0.82 | PTGDR2 (0.41) | SPRL3MBTL1PDE5AGRIN1GRIN2B | |
| SCHEMBL25974830 | 0.82 | KMT2A (0.44) | SPRL3MBTL1PDE5AKMT2ASLC22A12 | |
| SCHEMBL19264342 | 0.81 | L3MBTL1 (0.42) | SPRL3MBTL1PDE5AGRIN1GRIN2B | |
| SCHEMBL15937696 | 0.80 | PDE5A (0.32) | PDE5AGRIN2B | |
| SCHEMBL19264146 | 0.79 | L3MBTL1 (0.46) | SPRL3MBTL1PDE5AGRIN1GRIN2B | |
| SCHEMBL19151780 | 0.78 | PDE5A (0.50) | L3MBTL1PDE5A | |
| SCHEMBL15944483 | 0.78 | PDE5A (0.30) | PDE5A | |
| SCHEMBL19158700 | 0.76 | L3MBTL1 (0.47) | SPRL3MBTL1PDE5AADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729476-B1 | HETEROARYL SUBSTITUTED PYRAZOLOPYRIDINES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | BAYER IP GMBH (DE) | 2017-08-23 | — | — | EP | disclosed |