Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035398 | 0.87 | SMN1; SMN2 (0.62) | SMN1; SMN2GAAJAK2JAK1TYK2 | |
| SCHEMBL25630719 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4EALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL27659724 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2GAAJAK2JAK1TYK2 | |
| SCHEMBL25600474 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EALDH1A1PKM | |
| SCHEMBL25600475 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EALDH1A1PKM | |
| SCHEMBL25600476 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EALDH1A1PKM | |
| SCHEMBL27425161 | 0.81 | ACHE (0.45) | OPRK1 | |
| SCHEMBL4732821 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2GAAJAK2JAK1TYK2 | |
| SCHEMBL26263467 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EALDH1A1PKM | |
| SCHEMBL680627 | 0.79 | ACHE (0.47) | SMN1; SMN2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |