Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27659724 | 0.98 | SMN1; SMN2 (0.60) | SMN1; SMN2GAAKDM4EJAK2JAK1 | |
| SCHEMBL4732821 | 0.92 | SMN1; SMN2 (0.58) | SMN1; SMN2GAAKDM4EJAK2JAK1 | |
| Hydrochloric Acid SCHEMBL28764245 | 0.89 | SMN1; SMN2 (0.63) | SMN1; SMN2GAAKDM4EOPRK1 | |
| SCHEMBL23855249 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2GAAJAK2JAK1TYK2 | |
| SCHEMBL4730783 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2GAAJAK2JAK1TYK2 | |
| SCHEMBL1438737 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2GAAKDM4EJAK2JAK1 | |
| SCHEMBL3580053 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2GAAKDM4EJAK2JAK1 | |
| SCHEMBL19264191 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2GAAKDM4EJAK2JAK1 | |
| SCHEMBL14006406 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2GAAKDM4EJAK2JAK1 | |
| SCHEMBL30584719 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2GAAKDM4EJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035409-A1 | BENZIMIDAZOLE DERIVATIVES WHICH ARE TO BE USED AS ANATGONIST FOR THE CB1-RECEPTOR | AstraZeneca AB (SE) | 2009-03-18 | — | — | EP | claimed |
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | claimed |
| WO-2007145563-A1 | BENZIMIDAZOLE DERIVATIVES WHICH ARE TO BE USED AS ANTAGONIST FOR THE CB1-RECEPTOR | ASTRAZENECA AB (SE) | 2007-12-21 | — | — | WO | claimed |
| WO-2020225077-A1 | PYRIMIDO[4,5-B]INDOL DERIVATIVES AS PDHK1 INHIBITORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2020-11-12 | — | — | WO | disclosed |
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | disclosed |