Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10423801 | 0.74 | ALDH1A1 (0.34) | HCAR2SMN1; SMN2ALDH1A1MAPK1KDM4E | |
| SCHEMBL23781293 | 0.69 | LMNA (0.44) | SMN1; SMN2ALDH1A1MAPK1KDM4E | |
| SCHEMBL20028764 | 0.67 | NOTUM (0.46) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL19264701 | 0.67 | MEN1 (0.30) | ALDH1A1 | |
| SCHEMBL28710551 | 0.63 | NOTUM (0.50) | SMN1; SMN2KDM4E | |
| SCHEMBL10070241 | 0.61 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL18773508 | 0.61 | SCN9A (0.40) | NPC1MAPTRAB9A | |
| SCHEMBL13287986 | 0.61 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9437091 | 0.60 | NPSR1 (0.47) | HCAR2SMN1; SMN2ALDH1A1MAPK1KDM4E | |
| SCHEMBL3696308 | 0.58 | ALDH1A1 (0.36) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3208269-B1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-15 | — | — | EP | disclosed |
| EP-3208269-A1 | INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica N.V. (BE) | 2017-08-23 | — | — | EP | disclosed |