Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
| ▸ | QDPR | P09417 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 5/20 | 0.34 |
| ▸ | JAK2 | O60674 | 4/20 | 0.34 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345316 | 0.88 | TLR8 (0.48) | TLR8TLR7KITMAPTKDM4E | |
| SCHEMBL15496639 | 0.82 | TLR8 (0.47) | TLR8TLR7MAPTKDM4EALDH1A1 | |
| SCHEMBL19265669 | 0.81 | TLR8 (0.49) | TLR8TLR7MAPTALDH1A1JAK2 | |
| SCHEMBL19265485 | 0.80 | TLR8 (0.49) | TLR8TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL10345341 | 0.80 | TLR8 (0.45) | TLR8TLR7KITALDH1A1QDPR | |
| SCHEMBL18772121 | 0.72 | TLR8 (0.52) | TLR8TLR7ALDH1A1HPGD | |
| SCHEMBL18772071 | 0.72 | TLR8 (0.46) | TLR8TLR7MAPTKDM4EALDH1A1 | |
| SCHEMBL18772040 | 0.71 | TLR8 (0.45) | TLR8TLR7 | |
| SCHEMBL18772144 | 0.71 | TLR8 (0.45) | TLR8TLR7 | |
| SCHEMBL19416472 | 0.70 | TLR8 (0.43) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3208263-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | VentiRx Pharmaceuticals, Inc. (US) | 2017-08-23 | — | — | EP | disclosed |