Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032882 | 0.84 | TLR8 (0.61) | TLR8TLR7 | |
| SCHEMBL18772121 | 0.84 | TLR8 (0.52) | TLR8TLR7ALDH1A1 | |
| SCHEMBL19398238 | 0.83 | TLR8 (0.49) | TLR8TLR7ALDH1A1SMN1; SMN2ELANE | |
| SCHEMBL18772107 | 0.81 | TLR8 (0.50) | TLR8TLR7 | |
| SCHEMBL19416341 | 0.81 | MEN1 (0.45) | TLR8TLR7ALDH1A1MEN1MAPT | |
| SCHEMBL18772200 | 0.81 | TLR8 (0.50) | TLR8TLR7ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18772042 | 0.81 | TLR8 (0.49) | TLR8TLR7ALDH1A1MAPT | |
| SCHEMBL18771832 | 0.79 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL18771925 | 0.79 | TLR8 (0.45) | TLR8TLR7 | |
| SCHEMBL18772040 | 0.79 | TLR8 (0.45) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3225623-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-10-04 | — | — | EP | disclosed |
| EP-3159337-A2 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |