Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 3/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29971072 | 0.91 | PDPK1 (0.41) | PDPK1LOXL2L3MBTL1DYRK1ALOXL3 | |
| SCHEMBL28644252 | 0.91 | PDPK1 (0.41) | PDPK1LOXL2L3MBTL1DYRK1ALOXL3 | |
| SCHEMBL19274640 | 0.90 | LOXL2 (0.40) | PDPK1LOXL2MAPTL3MBTL1CNR2 | |
| SCHEMBL30699957 | 0.90 | LOXL2 (0.40) | PDPK1LOXL2MAPTL3MBTL1CNR2 | |
| SCHEMBL20983568 | 0.87 | LOXL2 (0.45) | PDPK1LOXL2L3MBTL1DYRK1ALOXL3 | |
| SCHEMBL19274748 | 0.86 | LOXL2 (0.37) | PDPK1LOXL2DYRK1ALOXL3 | |
| SCHEMBL19274631 | 0.86 | ESR1 (0.38) | PDPK1MAPTKMT2AL3MBTL1ESR1 | |
| SCHEMBL19274495 | 0.86 | PDPK1 (0.38) | PDPK1MAPTKMT2AL3MBTL1ESR1 | |
| SCHEMBL29971303 | 0.80 | LOXL2 (0.45) | PDPK1LOXL2LOXL3 | |
| SCHEMBL19259891 | 0.77 | LOXL2 (0.46) | PDPK1LOXL2DYRK1ALOXL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017141049-A1 | METHYLAMINE DERIVATIVES AS LYSYSL OXIDASE INHIBITORS FOR THE TREATMENT OF CANCER | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2017-08-24 | — | — | WO | disclosed |