Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19690265 | 0.88 | ALOX5 (0.45) | ALOX5ADAMTS5ALDH1A1TP53AR | |
| SCHEMBL19690264 | 0.88 | ALOX5 (0.45) | ALOX5ADAMTS5ALDH1A1TP53AR | |
| SCHEMBL18043595 | 0.84 | NOTUM (0.52) | ALOX5ALDH1A1TP53ARPOLB | |
| SCHEMBL18043606 | 0.82 | AR (0.47) | ALOX5OPRM1ALDH1A1ARHPGD | |
| SCHEMBL19385695 | 0.82 | AR (0.47) | ALOX5OPRM1ALDH1A1ARHPGD | |
| SCHEMBL23777680 | 0.82 | ADAMTS5 (0.54) | ADAMTS5ALDH1A1TP53MGLLHPGD | |
| SCHEMBL11963050 | 0.82 | ADAMTS5 (0.54) | ADAMTS5ALDH1A1TP53MGLLHPGD | |
| SCHEMBL23777797 | 0.82 | ADAMTS5 (0.54) | ADAMTS5ALDH1A1TP53MGLLHPGD | |
| SCHEMBL19690137 | 0.81 | USP30 (0.50) | ALOX5 | |
| SCHEMBL19690138 | 0.81 | USP30 (0.50) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209664-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-30 | — | — | EP | disclosed |