Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.68 |
| ▸ | BCR | P11274 | 18/20 | 0.68 |
| ▸ | SRC | P12931 | 7/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.68 |
| ▸ | SYK | P43405 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 2/20 | 0.65 |
| ▸ | PRKCA | P17252 | 4/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PRKCG | P05129 | 1/20 | 0.58 |
| ▸ | PRKCB | P05771 | 1/20 | 0.58 |
| ▸ | PRKCH | P24723 | 1/20 | 0.58 |
| ▸ | PRKCI | P41743 | 1/20 | 0.58 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.58 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.58 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 4/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035935 | 0.83 | ABL1 (0.60) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL4894465 | 0.82 | ABL1 (0.73) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL9485 | 0.81 | ABL1 (1.00) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL2624940 | 0.80 | ABL1 (0.82) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL6258131 | 0.79 | ABL1 (1.00) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL8261009 | 0.79 | ABL1 (0.94) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL3866664 | 0.79 | ABL1 (0.94) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL7465138 | 0.78 | ABL1 (0.80) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL1655099 | 0.77 | ABL1 (1.00) | ABL1BCRSRCPDGFRAPDGFRB | |
| SCHEMBL6239405 | 0.77 | ABL1 (0.86) | ABL1BCRSRCPDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2368889-A1 | Inhibitors of tyrosine kinases | Novartis AG (CH) | 2011-09-28 | — | — | EP | disclosed |
| US-20110218187-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2011-09-08 | — | — | US | disclosed |
| US-7956053-B2 | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2011-06-07 | — | — | US | disclosed |
| US-20090286821-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2009-11-19 | — | — | US | disclosed |
| EP-2100891-A1 | Inhibitors of tyrosine kinases | Novartis AG (CH) | 2009-09-16 | — | — | EP | disclosed |
| US-7569566-B2 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | NOVARTIS AG (CH) | 2009-08-04 | — | — | US | disclosed |
| US-20080188451-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2008-08-07 | — | — | US | disclosed |
| US-20070093506-A1 | Inhibitors of tyrosine kinases | BREITENSTEIN WERNER | 2007-04-26 | — | — | US | disclosed |
| US-7169791-B2 | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2007-01-30 | — | — | US | disclosed |
| US-20060167015-A1 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | NOVARTIS AG (CH) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093506-A1 | Inhibitors of tyrosine kinases | ABL1, BTK, FLT3 | ABL1 1/4885BCR 28/4885SRC 8/4885 |
| US-20110218187-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | ABL1 1/4885BCR 28/4885SRC 8/4885 |
| US-20080188451-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | ABL1 1/4885BCR 28/4885SRC 8/4885 |
| US-20090286821-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | ABL1 1/4885BCR 28/4885SRC 8/4885 |
| US-20060167015-A1 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | ABL1, CDK2, CDKN1A | ABL1 1/4885BCR 181/4885SRC 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.