Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521041 | 0.81 | DRD2 (0.36) | SIGMAR1DRD2DRD4SLC6A2DRD3 | |
| SCHEMBL17354971 | 0.80 | KMT2A (0.35) | SIGMAR1DRD2DRD4SLC6A2DRD3 | |
| SCHEMBL3648918 | 0.75 | RECQL (0.38) | SIGMAR1CHRM2CHRM4CHRM5L3MBTL1 | |
| SCHEMBL1513406 | 0.72 | SLC6A2 (0.49) | SIGMAR1SLC6A2CHRM2CHRM4CHRM5 | |
| SCHEMBL1334034 | 0.71 | BCHE (0.44) | DRD2DRD4DRD3CHRM2CHRM5 | |
| SCHEMBL1631113 | 0.70 | SMN1; SMN2 (0.39) | KMT2AOPRK1 | |
| SCHEMBL1206554 | 0.69 | SIGMAR1 (0.51) | SIGMAR1DRD2DRD4SLC6A2DRD3 | |
| SCHEMBL1335697 | 0.69 | SLC6A2 (0.39) | SIGMAR1DRD2DRD4SLC6A2DRD3 | |
| SCHEMBL24581714 | 0.69 | SIGMAR1 (0.39) | SIGMAR1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL9911016 | 0.68 | SLC6A2 (0.42) | SIGMAR1DRD2DRD4SLC6A2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350068-B1 | UREA DERIVATIVES OF SUBSTITUTED NORTROPANES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INT (DE) | 2017-08-30 | — | — | EP | disclosed |