Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055828 | 0.87 | GAA (0.40) | RORCHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14886670 | 0.84 | GSK3B (0.52) | HPGDHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9997230 | 0.79 | ACLY (0.45) | HPGDRAB9APKMGAAFFAR1 | |
| SCHEMBL15056190 | 0.79 | GSK3B (0.43) | RORCHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19165774 | 0.78 | HPGD (0.63) | RORCHPGDRAB9APLAUMAPT | |
| SCHEMBL19165142 | 0.78 | RORC (0.63) | RORCHPGDPLAUCA12CA1 | |
| SCHEMBL19165140 | 0.77 | HPGD (0.59) | RORCHPGDSMN1; SMN2RAB9APLAU | |
| SCHEMBL19165715 | 0.77 | RORC (0.61) | RORCHPGDRAB9APLAUMAPT | |
| SCHEMBL19165143 | 0.77 | HPGD (0.59) | RORCHPGDHDAC8SMN1; SMN2RAB9A | |
| SCHEMBL19165139 | 0.76 | RORC (0.58) | RORCHPGDRAB9APLAUMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794009-B1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2017-08-30 | — | — | EP | disclosed |
| US-9174954-B2 | 3,7-diamino-10H-phenothiazine salts and their use | WISTA LABORATORIES LTD. (SG) | 2015-11-03 | — | — | US | disclosed |