Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21709591 | 0.84 | ALK (0.51) | ALKINSRIGF1RLRRK2 | |
| SCHEMBL11916339 | 0.83 | ALK (0.55) | ALKINSRIGF1RLRRK2EGFR | |
| SCHEMBL17527347 | 0.78 | ALK (0.47) | ALKINSRLRRK2EGFRROS1 | |
| SCHEMBL11900440 | 0.78 | ALK (0.47) | ALKINSREGFRROS1 | |
| SCHEMBL21709590 | 0.75 | ALK (0.42) | ALKINSRIGF1REGFR | |
| SCHEMBL17527454 | 0.74 | ALK (0.59) | ALKINSRIGF1RLRRK2EGFR | |
| SCHEMBL11901894 | 0.74 | ALK (0.59) | ALKINSRIGF1RLRRK2EGFR | |
| SCHEMBL11901898 | 0.74 | ALK (0.59) | ALKINSRIGF1RLRRK2EGFR | |
| SCHEMBL11900492 | 0.68 | ALK (0.54) | ALKINSRIGF1RLRRK2EGFR | |
| SCHEMBL17527282 | 0.66 | ALK (0.60) | ALKINSRIGF1RLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3210609-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2017-08-30 | — | — | EP | disclosed |