Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CCR3 | P51677 | 3/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18435161 | 0.91 | LMNA (0.57) | LMNASMN1; SMN2MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL18435159 | 0.91 | LMNA (0.57) | LMNASMN1; SMN2MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL16254307 | 0.86 | LMNA (0.60) | LMNASMN1; SMN2MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL19289959 | 0.84 | MEN1 (0.52) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4163972 | 0.81 | TACR1 (0.64) | — | |
| SCHEMBL16254339 | 0.79 | LMNA (0.62) | LMNASMN1; SMN2MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL18197715 | 0.78 | MAPT (0.57) | LMNASMN1; SMN2MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL7384641 | 0.76 | LMNA (0.58) | LMNASMN1; SMN2MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL4599032 | 0.75 | MAPT (0.60) | LMNASMN1; SMN2MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL16252298 | 0.74 | MEN1 (0.55) | SMN1; SMN2MAPK1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861581-B9 | 1,2,3,4-Tetrahydroisoquinoline-pyrrolidine derivatives as antagonists of apoptosis (IAPs) for the treatment of cancer. | BRISTOL MYERS SQUIBB CO (US) | 2017-08-30 | — | — | EP | disclosed |