Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21428954 | 0.85 | PPARG (0.52) | GPR34PPARGMMEFAAHMMP2 | |
| SCHEMBL28809944 | 0.85 | PPARG (0.52) | GPR34PPARGMMEFAAHMMP2 | |
| SCHEMBL6372114 | 0.85 | LMNA (0.51) | LMNAMAPK1SMN1; SMN2HSD17B10L3MBTL1 | |
| SCHEMBL6372110 | 0.85 | LMNA (0.51) | LMNAMAPK1SMN1; SMN2HSD17B10L3MBTL1 | |
| SCHEMBL1533647 | 0.81 | PPARG (0.58) | PPARGFOLH1MMEMMP2MMP9 | |
| SCHEMBL6250861 | 0.81 | PPARG (0.58) | PPARGFOLH1MMEMMP2MMP9 | |
| SCHEMBL1533645 | 0.81 | PPARG (0.58) | PPARGFOLH1MMEMMP2MMP9 | |
| SCHEMBL6373349 | 0.81 | FPR2 (0.60) | LMNAGPR34ALDH1A1MAPTMEN1 | |
| SCHEMBL16254307 | 0.80 | LMNA (0.60) | LMNAGPR34MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL5906957 | 0.79 | FPR2 (0.53) | LMNAPPARGL3MBTL1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291511-B1 | Biarylalkanoic acids as cell adhesion inhibitors | MERCK & CO., INC. | 2001-09-18 | — | — | US | disclosed |
| EP-1017382-A4 | BIARYLALKANOIC ACIDS AS CELL ADHESION INHIBITORS | MERCK & CO INC (US) | 2000-08-30 | — | — | EP | disclosed |
| EP-1017382-A1 | BIARYLALKANOIC ACIDS AS CELL ADHESION INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-1998053817-A1 | BIARYLALKANOIC ACIDS AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 1998-12-03 | — | — | WO | disclosed |