Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | ACACB | O00763 | 9/20 | 0.69 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927935 | 0.86 | GRM5 (0.65) | GAAKMT2AHSD17B10ACACBALOX5 | |
| SCHEMBL255736 | 0.82 | ACACB (1.00) | ACACB | |
| SCHEMBL1927534 | 0.81 | L3MBTL1 (0.61) | GAAACACBHPGDALOX5EPHX2 | |
| SCHEMBL255251 | 0.81 | GAA (0.76) | GAAKMT2AHSD17B10GPR139HPGD | |
| SCHEMBL1928381 | 0.81 | GAA (0.76) | GAAKMT2AHSD17B10HPGDEPHX2 | |
| SCHEMBL31331780 | 0.81 | GAA (0.76) | GAAKMT2AHSD17B10HPGDEPHX2 | |
| SCHEMBL27727377 | 0.80 | GAA (0.87) | GAAKMT2AHSD17B10ACACBHPGD | |
| SCHEMBL1927040 | 0.79 | SMN1; SMN2 (0.70) | GAAKMT2AACACBALOX5EPHX2 | |
| SCHEMBL1927069 | 0.78 | NPC1 (0.51) | GAAKMT2AACACBHPGDALOX5 | |
| SCHEMBL161880 | 0.77 | GAA (0.81) | GAAKMT2AHSD17B10ACACBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-B1 | ALPHA-HELICAL MIMETICS | WALTER & ELIZA HALL INST MEDICAL RES (AU) | 2018-02-21 | — | — | EP | disclosed |
| US-7956216-B2 | Benzoyl urea derivatives mimicing BH3-only proteins, able to interact with a Bcl-2 protein | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2011-06-07 | — | — | US | disclosed |
| US-20080153802-A1 | Alpha-helical mimetics | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2008-06-26 | — | — | US | disclosed |
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153802-A1 | Alpha-helical mimetics | BID, BAX, BAD | GAA 1917/4885KMT2A 2959/4885HSD17B10 4090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.