Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | ITK | Q08881 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | STK16 | O75716 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | MST1R | Q04912 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.50 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297760 | 0.91 | EGFR (0.45) | SYKEGFRITKAURKAPTK2 | |
| SCHEMBL19297745 | 0.89 | BCL6 (0.56) | SYKEGFRITKAURKAPTK2 | |
| SCHEMBL19297712 | 0.88 | AURKA (0.50) | SYKEGFRITKAURKAJAK2 | |
| SCHEMBL14837338 | 0.84 | SYK (0.55) | SYKEGFRITKAURKAJAK2 | |
| SCHEMBL19297751 | 0.84 | SYK (0.54) | SYKEGFRITKAURKAJAK2 | |
| SCHEMBL19297758 | 0.83 | SYK (0.60) | SYKAURKAMAPK8AURKB | |
| SCHEMBL19297727 | 0.83 | SYK (0.54) | SYKEGFRITKAURKAJAK2 | |
| SCHEMBL19297735 | 0.82 | SYK (0.55) | SYKEGFRCDC7ROCK2CDK1 | |
| SCHEMBL19297730 | 0.81 | SYK (0.43) | SYKEGFRITKAURKAJAK2 | |
| SCHEMBL19297756 | 0.81 | CDK1 (0.46) | SYKEGFRITKAURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751893-B2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | claimed |