Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297712 | 0.87 | AURKA (0.50) | SYKCDK1EGFRFGFR1 | |
| SCHEMBL19297756 | 0.85 | CDK1 (0.46) | SYKCDK1EGFRFGFR1 | |
| SCHEMBL12389624 | 0.84 | SYK (0.57) | SYKPDGFRBPDGFRACDC7CDK1 | |
| SCHEMBL19297758 | 0.83 | SYK (0.60) | SYK | |
| SCHEMBL19297760 | 0.83 | EGFR (0.45) | SYKEGFR | |
| SCHEMBL12389631 | 0.82 | SYK (0.57) | SYKPDGFRBPDGFRACDC7CDK1 | |
| SCHEMBL12389643 | 0.82 | SYK (0.58) | SYKPDGFRBPDGFRACDC7CDK1 | |
| SCHEMBL19297724 | 0.82 | SYK (0.53) | SYKPDGFRBPDGFRACDC7CDK1 | |
| SCHEMBL19297730 | 0.82 | SYK (0.43) | SYKCDK1EGFRFGFR1 | |
| SCHEMBL19297745 | 0.81 | BCL6 (0.56) | SYKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751893-B2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | claimed |