Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 12/20 | 0.43 |
| ▸ | AURKA | O14965 | 6/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | LYN | P07948 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297712 | 0.87 | AURKA (0.50) | CDK1SYKAURKAJAK3JAK2 | |
| SCHEMBL19297735 | 0.85 | SYK (0.55) | CDK1SYKFGFR1EGFR | |
| SCHEMBL19297714 | 0.83 | CDK1 (0.40) | CDK1SYKAURKAJAK3JAK1 | |
| SCHEMBL19297758 | 0.82 | SYK (0.60) | SYKAURKAMAPK8AURKB | |
| SCHEMBL19297760 | 0.82 | EGFR (0.45) | SYKAURKAPTK2BTKITK | |
| SCHEMBL19297730 | 0.81 | SYK (0.43) | CDK1SYKAURKAJAK3JAK1 | |
| SCHEMBL19297724 | 0.81 | SYK (0.53) | CDK1SYKAURKAJAK3JAK1 | |
| SCHEMBL19297745 | 0.80 | BCL6 (0.56) | SYKAURKAPTK2ITKSTK17A | |
| SCHEMBL3955918 | 0.79 | BCL6 (0.47) | CDK1SYKAURKAJAK2LCK | |
| SCHEMBL1135756 | 0.77 | CDK1 (0.51) | CDK1SYKAURKAJAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751893-B2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | claimed |