Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19525867 | 0.84 | NPSR1 (0.44) | NPSR1ALDH1A1ALOX15CYP2D6SMN1; SMN2 | |
| SCHEMBL24215447 | 0.74 | — | — | |
| SCHEMBL23367239 | 0.74 | — | — | |
| Guanidine SCHEMBL7768987 | 0.74 | ALOX15 (0.50) | NPSR1ALDH1A1ALOX15CYP2D6SMN1; SMN2 | |
| SCHEMBL20938293 | 0.73 | NPSR1 (0.45) | NPSR1ALDH1A1ALOX15CYP2D6SMN1; SMN2 | |
| SCHEMBL19687288 | 0.73 | NPSR1 (0.41) | NPSR1ALDH1A1ALOX15CYP2D6SMN1; SMN2 | |
| SCHEMBL208479 | 0.73 | — | — | |
| SCHEMBL22903104 | 0.73 | NPSR1 (0.41) | NPSR1ALDH1A1ALOX15CYP2D6SMN1; SMN2 | |
| SCHEMBL21128303 | 0.72 | NPSR1 (0.44) | NPSR1ALDH1A1ALOX15CYP2D6SMN1; SMN2 | |
| SCHEMBL21236162 | 0.72 | MAPT (0.38) | NPSR1ALDH1A1CYP2D6SMN1; SMN2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3419979-B1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER (US) | 2020-01-29 | — | — | EP | disclosed |
| WO-2017145013-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |