Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA4 | P22748 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA7 | P43166 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GGT1 | P19440 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL1896603 | 0.96 | ALDH1A1 (0.61) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL10484670 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL29098718 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL29726051 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL29098716 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL192153 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL29098715 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL589207 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL7030041 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 | |
| Phthalic Acid SCHEMBL7030044 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15KDM4EHPGDCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440001-B2 | Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same | ABELA PHARMACEUTICALS, INC. (US) | 2013-05-14 | — | — | US | claimed |
| US-20130052112-A1 | SYSTEMS FOR REMOVING DIMETHYL SULFOXIDE (DMSO) OR RELATED COMPOUNDS, OR ODORS ASSOCIATED WITH SAME | ABELA PHARMACEUTICALS, INC. (US) | 2013-02-28 | — | — | US | claimed |
| US-6844430-B2 | Articles comprising cationic polysaccharides and acidic pH buffering means | THE PROCTOR & GAMBLE COMPANY (US) | 2005-01-18 | — | — | US | claimed |
| US-9186472-B2 | Devices for removal of dimethyl sulfoxide (DMSO) or related compounds or associated odors and methods of using same | ABELA PHARMACEUTICALS, INC. (US) | 2015-11-17 | — | — | US | disclosed |
| EP-1966229-B1 | SYSTEMS FOR REMOVING DIMETHYL SULFOXIDE (DMSO) OR RELATED COMPOUNDS, OR ODORS ASSOCIATED WITH SAME | ABELA PHARMACEUTICALS INC (US) | 2015-10-21 | — | — | EP | disclosed |
| US-20140116444-A1 | DEVICES FOR REMOVAL OF DIMETHYL SULFOXIDE (DMSO) OR RELATED COMPOUNDS OR ASSOCIATED ODORS AND METHODS OF USING SAME | ABELA PHARMACEUTICALS, INC. (US) | 2014-05-01 | — | — | US | disclosed |
| US-8673061-B2 | Methods for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors | ABELA PHARMACEUTICALS, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8480797-B2 | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors | ABELA PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8440001-B2 | Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same | ABELA PHARMACEUTICALS, INC. (US) | 2013-05-14 | — | — | US | disclosed |
| US-20130052112-A1 | SYSTEMS FOR REMOVING DIMETHYL SULFOXIDE (DMSO) OR RELATED COMPOUNDS, OR ODORS ASSOCIATED WITH SAME | ABELA PHARMACEUTICALS, INC. (US) | 2013-02-28 | — | — | US | disclosed |
| US-8298320-B2 | Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same | ABELA PHARMACEUTICALS, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| US-20110203585-A1 | ACTIVATED CARBON SYSTEMS FOR FACILITATING USE OF DIMETHYL SULFOXIDE (DMSO) BY REMOVAL OF SAME, RELATED COMPOUNDS, OR ASSOCIATED ODORS | ABELA PHARMACEUTICALS, INC. (US) | 2011-08-25 | — | — | US | disclosed |
| US-20110203584-A1 | SYSTEMS FOR REMOVING DIMETHYL SULFOXIDE (DMSO) OR RELATED COMPOUNDS, OR ODORS ASSOCIATED WITH SAME | ABELA PHARMACEUTICALS, INC. (US) | 2011-08-25 | — | — | US | disclosed |
| US-20110203583-A1 | METHODS FOR FACILITATING USE OF DIMETHYL SULFOXIDE (DMSO) BY REMOVAL OF SAME, RELATED COMPOUNDS, OR ASSOCIATED ODORS | ABELA PHARMACEUTICALS, INC. (US) | 2011-08-25 | — | — | US | disclosed |
| EP-2346575-A1 | ACTIVATED CARBON SYSTEMS FOR FACILITATING USE OR TREATMENT WITH DIMETHYL SULFOXIDE (DMSO) | Abela Pharmaceuticals, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| US-7955418-B2 | Systems for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated with same | ABELA PHARMACEUTICALS, INC. (US) | 2011-06-07 | — | — | US | disclosed |
| WO-2010062721-A1 | ACTIVATED CARBON SYSTEMS FOR FACILITATING USE OR TREATMENT WITH DIMETHYL SULFOXIDE (DMSO) | ABELA PHARMACEUTICALS, INC. (US) | 2010-06-03 | — | — | WO | disclosed |
| US-20080251081-A1 | Systems for Removing Dimethyl Sulfoxide (Dmso) or Related Compounds or Odors Associated with Same | ABELA PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| EP-1966229-A2 | SYSTEMS FOR REMOVING DIMETHYL SULFOXIDE (DMSO) OR RELATED COMPOUNDS, OR ODORS ASSOCIATED WITH SAME | Abela Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007033083-A2 | SYSTEMS FOR REMOVING DIMETHYL SULFOXIDE (DMSO) OR RELATED COMPOUNDS, OR ODORS ASSOCIATED WITH SAME | ABELA PHARMACEUTICALS, INC. (US) | 2007-03-22 | — | — | WO | disclosed |