Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 10/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.42 |
| ▸ | TEK | Q02763 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19300044 | 0.85 | KLKB1 (0.46) | KLKB1HSD17B10KDREPHB4TEK | |
| SCHEMBL27364232 | 0.84 | KLKB1 (0.53) | KLKB1HSD17B10LMNAMAPTALDH1A1 | |
| SCHEMBL948453 | 0.81 | HSD17B10 (0.61) | KLKB1HSD17B10LMNAMAPTALDH1A1 | |
| SCHEMBL949612 | 0.81 | KLKB1 (0.53) | KLKB1HSD17B10LMNAALDH1A1POLB | |
| SCHEMBL19304489 | 0.80 | KLKB1 (0.43) | KLKB1HSD17B10KDREPHB4TEK | |
| SCHEMBL17696410 | 0.80 | KLKB1 (0.55) | KLKB1HSD17B10LMNAALDH1A1POLB | |
| SCHEMBL15759268 | 0.78 | KLKB1 (0.51) | KLKB1HSD17B10KDREPHB4TEK | |
| SCHEMBL3593783 | 0.77 | MAPT (0.68) | KLKB1HSD17B10KDREPHB4TEK | |
| SCHEMBL2821953 | 0.77 | LMNA (0.54) | KLKB1HSD17B10LMNAMAPTALDH1A1 | |
| SCHEMBL2821950 | 0.76 | HSD17B10 (0.43) | KLKB1HSD17B10KDREPHB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144995-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |