Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19301626 | 0.81 | NOTUM (0.38) | NOTUMCNR2KDM2BPTGER4MEN1 | |
| SCHEMBL19301628 | 0.76 | S1PR1 (0.46) | MEN1TSHRKMT2A | |
| SCHEMBL19301728 | 0.72 | BRD4 (0.51) | NOTUMMEN1TSHRKMT2ALMNA | |
| SCHEMBL13268574 | 0.71 | AR (0.49) | TP53TSHRKMT2ALMNA | |
| SCHEMBL19301650 | 0.68 | NOTUM (0.46) | NOTUMCNR2GRIA2GRIN2AMEN1 | |
| SCHEMBL19301719 | 0.67 | NOTUM (0.41) | NOTUMCNR2GRIA2GRIN2ACNR1 | |
| SCHEMBL19301648 | 0.66 | NOTUM (0.41) | NOTUMCNR2GRIA2GRIN2ACNR1 | |
| SCHEMBL19301649 | 0.65 | GRIA2 (0.43) | NOTUMCNR2GRIA2GRIN2AMEN1 | |
| SCHEMBL31708636 | 0.65 | CNR2 (0.39) | CNR2KDM2BPTGER4CECR2CYP1A2 | |
| SCHEMBL4637505 | 0.64 | TDP1 (0.42) | NOTUMCNR2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11198681-B2 | Heteroaryl inhibitors of PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2021-12-14 | — | — | US | disclosed |
| US-20210188810-A1 | HETEROARYL INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS INC (US) | 2021-06-24 | — | — | US | disclosed |
| WO-2017147102-A1 | HETEROARYL INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2017-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188810-A1 | HETEROARYL INHIBITORS OF PAD4 | PADI4, PADI1, PADI6 | NOTUM 1117/4885CNR2 4604/4885KDM2B 263/4885 |
| US-11198681-B2 | Heteroaryl inhibitors of PAD4 | PADI4, PADI1, PADI6 | NOTUM 1117/4885CNR2 4604/4885KDM2B 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.