PADI6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29453253	1.00	3/20
SCHEMBL2701630	0.73	3/20
SCHEMBL10026327	0.72	3/20
SCHEMBL28476721	0.72	3/20
SCHEMBL10060225	0.67	3/20
SCHEMBL16124409	0.61	3/20
SCHEMBL10060238	0.55	3/20
SCHEMBL30228663	1.00	2/20
SCHEMBL31378276	1.00	2/20
SCHEMBL31378277	1.00	2/20
Trifluoroacetic Acid (SCHEMBL29636638)	0.87	2/20
SCHEMBL10060224	0.82	2/20
SCHEMBL10061252	0.81	2/20
SCHEMBL29392045	0.78	2/20
SCHEMBL2699874	0.74	2/20
SCHEMBL2699878	0.74	2/20
SCHEMBL16124246	0.72	2/20
Trifluoroacetic Acid (SCHEMBL25368073)	0.70	2/20
SCHEMBL10060566	0.69	2/20
SCHEMBL1979621	0.66	2/20

Clinical trials — most relevant to PADI6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-Arginine Role for Stone Lower Ureter : A Randomized Control Study	PHASE4	COMPLETED
L-arginine Treatment in Mild Hypertension	PHASE4	UNKNOWN
Abatacept to Silence Anti-citrullinated Protein Antibody-expressing B Cells in Rheumatoid Arthritis (ASCARA)	PHASE4	COMPLETED
Vascular Function Intervention Trial in Sickle Cell Disease	PHASE2/PHASE3	UNKNOWN
L-Arginine in Pre-Eclampsia	PHASE3	COMPLETED
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis	PHASE2	RECRUITING
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19	PHASE2	COMPLETED
ADI-PEG20, Obesity and Prediabetes	PHASE2	WITHDRAWN
The Effects of NOx and Conjugated Linoleic Acid on Asthmatics	PHASE2	COMPLETED
The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension	PHASE2	COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation.	EARLY_PHASE1	COMPLETED
Study of the Articular Microbiota in Rheumatoid Arthritis.	nan	COMPLETED
Effect of Nonsurgical Periodontal Therapy (NSPT) on Rheumatoid Arthritis Subjects With Periodontitis	nan	COMPLETED
Serum Anti-PCOLCE as Novel Diagnostic Biomarker in Rheumatoid Arthritis With Emphasis on Seronegative Patients.	nan	NOT_YET_RECRUITING
Impact of Antiglycemic & Immunosuppressive Therapies on NETosis in Diabetes & Kidney Disease (NETs - Neutrophil Traps)	nan	RECRUITING
Effects of Trehalose and Polyphenols in Vasculopathic Patients	nan	COMPLETED
Identification of Acute Intermittent Porphyria Modifying Genes	nan	RECRUITING
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial	nan	COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease	nan	COMPLETED
L-Arginine, Symmetrical and Asymmetrical Dimethylarginine (SDMA/ADMA) in Acute Kidney Injury (AKI)	nan	COMPLETED
Arginine Synthesis in Healthy Adult Humans	nan	COMPLETED
Preterm Arginine INTake Study	nan	COMPLETED
Effect Assessment of Periodontal Prophylaxis on Rheumatoid Arthritis Activity.	nan	COMPLETED
Study of Arginine and Nitric Oxide in Patients With Diabetes	nan	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Effects of Citrulline on Gut Functioning During Excercise	nan	UNKNOWN
High Definition Profiling of Ovarian Cancer Ascites	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PADI6 binder may also engage these)

Protein	Name	Similarity
Q8K3V4	—	1.000	Q8K3V4 →
PADI2	Protein-arginine deiminase type-2	0.999	landscape →
Q08642	—	0.996	Q08642 →
P20717	—	0.995	P20717 →
PADI1	Protein-arginine deiminase type-1	0.995	landscape →
O88807	—	0.995	O88807 →
PADI4	Protein-arginine deiminase type-4	0.994	landscape →
Q9Z185	—	0.992	Q9Z185 →
Q9Z184	—	0.992	Q9Z184 →
Q8TDB6	—	0.991	Q8TDB6 →
PADI3	Protein-arginine deiminase type-3	0.990	landscape →
Q9Z183	—	0.990	Q9Z183 →
O88806	—	0.990	O88806 →
P70708	—	0.990	P70708 →
Q9D5Z5	—	0.987	Q9D5Z5 →
P0DP43	—	0.987	P0DP43 →
B5E0H4	—	0.986	B5E0H4 →
AS3MT	Arsenite methyltransferase	0.986	landscape →
O02849	—	0.986	O02849 →
A8E7C5	—	0.986	A8E7C5 →
Q6GM71	—	0.986	Q6GM71 →
Q8BMD7	—	0.986	Q8BMD7 →
B4GH42	—	0.986	B4GH42 →
Q8BJM7	—	0.986	Q8BJM7 →
Q4V9P9	—	0.985	Q4V9P9 →
Q9VCB1	—	0.985	Q9VCB1 →
Q5R5W9	—	0.985	Q5R5W9 →
Q9M3B6	—	0.985	Q9M3B6 →
Q2QEI3	—	0.985	Q2QEI3 →
Q6IND4	—	0.985	Q6IND4 →