Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 7/20 | 0.37 |
| ▸ | HTR2C | P28335 | 6/20 | 0.37 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17724238 | 0.82 | CRBN (0.54) | CRBNDDB1IKZF3CSNK1A1IKZF1 | |
| SCHEMBL17724229 | 0.82 | CRBN (0.54) | CRBNDDB1IKZF3CSNK1A1IKZF1 | |
| SCHEMBL17724108 | 0.82 | CRBN (0.54) | CRBNDDB1IKZF3CSNK1A1IKZF1 | |
| SCHEMBL19305483 | 0.79 | HTR2C (0.41) | PARP1HTR2BHTR2CHTR2A | |
| SCHEMBL30493286 | 0.78 | STAT3 (0.44) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL23938928 | 0.74 | THRB (0.37) | MAPK1PTGER2 | |
| SCHEMBL17724086 | 0.74 | TNF (0.61) | CRBNDDB1IKZF3CSNK1A1IKZF1 | |
| SCHEMBL17724223 | 0.74 | TNF (0.61) | CRBNDDB1IKZF3CSNK1A1IKZF1 | |
| SCHEMBL19541607 | 0.74 | CRBN (0.40) | CRBNDDB1IKZF3CSNK1A1IKZF1 | |
| SCHEMBL17724215 | 0.74 | TNF (0.61) | CRBNDDB1IKZF3CSNK1A1IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3214081-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Kangpu Biopharmaceuticals, Ltd. (CN) | 2017-09-06 | — | — | EP | disclosed |