Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 5/20 | 0.44 |
| ▸ | NPY4R | P50391 | 5/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.35 |
| ▸ | NPY1R | P25929 | 4/20 | 0.35 |
| ▸ | NPY2R | P49146 | 2/20 | 0.35 |
| ▸ | FURIN | P09958 | 2/20 | 0.35 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20808481 | 0.95 | FAP (0.44) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL16266215 | 0.95 | FAP (0.44) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL20000725 | 0.95 | FAP (0.44) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL16266214 | 0.95 | FAP (0.44) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL24520454 | 0.89 | FAP (0.47) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL22952275 | 0.89 | FAP (0.44) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL21416485 | 0.89 | FAP (0.44) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL9943152 | 0.89 | FAP (0.47) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL3244447 | 0.89 | FAP (0.44) | FAPNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL16266184 | 0.89 | FAP (0.44) | FAPNPY4RNPY5RNPY1RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423457-B1 | PROCESS FOR THE PREPARATION OF AN ANTIBODY-RIFAMYCIN CONJUGATE | HOFFMANN LA ROCHE (CH) | 2021-02-17 | — | — | EP | disclosed |
| US-10689325-B2 | Process for the preparation of an antibody-rifamycin conjugate | GENENTECH, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190270695-A1 | PROCESS FOR THE PREPARATION OF AN ANTIBODY-RIFAMYCIN CONJUGATE | GENENTECH, INC. (US) | 2019-09-05 | — | — | US | disclosed |
| US-10336683-B2 | Process for the preparation of an antibody-rifamycin conjugate | GENENTECH, INC. (US) | 2019-07-02 | — | — | US | disclosed |
| EP-3423457-A1 | PROCESS FOR THE PREPARATION OF AN ANTIBODY-RIFAMYCIN CONJUGATE | H. Hoffnabb-La Roche Ag (CH) | 2019-01-09 | — | — | EP | disclosed |
| US-20170252457-A1 | PROCESS FOR THE PREPARATION OF AN ANTIBODY-RIFAMYCIN CONJUGATE | GENENTECH, INC. (US) | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336683-B2 | Process for the preparation of an antibody-rifamycin conjugate | FUCA2, MRPL21, FNTB | FAP 1496/4885NPY4R 3905/4885NPY5R 3826/4885 |
| US-20190270695-A1 | PROCESS FOR THE PREPARATION OF AN ANTIBODY-RIFAMYCIN CONJUGATE | FUCA2, MRPL21, FNTB | FAP 1496/4885NPY4R 3905/4885NPY5R 3826/4885 |
| US-10689325-B2 | Process for the preparation of an antibody-rifamycin conjugate | FUCA2, MRPL21, FNTB | FAP 1496/4885NPY4R 3905/4885NPY5R 3826/4885 |
| US-20170252457-A1 | PROCESS FOR THE PREPARATION OF AN ANTIBODY-RIFAMYCIN CONJUGATE | FUCA2, MRPL21, FNTB | FAP 1496/4885NPY4R 3905/4885NPY5R 3826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.