Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 3/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930847 | 1.00 | CTSS (0.36) | CTSSCTSKUSP2SMN1; SMN2RECQL | |
| SCHEMBL20241775 | 0.89 | CTSS (0.43) | CTSSCTSKSMN1; SMN2CA12CA14 | |
| SCHEMBL28077247 | 0.79 | CTSK (0.45) | CTSSCTSKAAK1 | |
| SCHEMBL2199576 | 0.79 | CTSK (0.53) | CTSSCTSKCA12CA14AAK1 | |
| SCHEMBL2199572 | 0.79 | CTSK (0.53) | CTSSCTSKCA12CA14AAK1 | |
| SCHEMBL16800 | 0.79 | CTSK (0.53) | CTSSCTSKCA12CA14AAK1 | |
| SCHEMBL18497396 | 0.75 | KDM4E (0.49) | USP2SMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL12091408 | 0.74 | PIK3CD (0.37) | CTSKCA14NAAAGCKKMT2A | |
| SCHEMBL1711663 | 0.74 | PIK3CD (0.33) | CNR2CNR1NAAAGCKKMT2A | |
| SCHEMBL1711666 | 0.74 | PIK3CD (0.33) | CNR2CNR1NAAAGCKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071606-B2 | Substituted pyrazinone amides useful for activation of glucokinase | PFIZER INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20110130365-A1 | Fluorinated Heteroaryls | BENBOW JOHN W | 2011-06-02 | — | — | US | disclosed |
| US-20100184777-A1 | Substituted Pyrazinone Amides | PFIZER INC | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184777-A1 | Substituted Pyrazinone Amides | GCK, GCKR, PDK2 | CTSS 1574/4885CTSK 259/4885USP2 4310/4885 |
| US-20110130365-A1 | Fluorinated Heteroaryls | GCKR, GALK1, GCK | CTSS 1972/4885CTSK 659/4885USP2 4193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.