Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16367153 | 0.83 | ALDH1A1 (0.42) | ALDH1A1TDP1SMN1; SMN2SIGMAR1KMT2A | |
| SCHEMBL8023138 | 0.82 | ALDH1A1 (0.67) | ALDH1A1TDP1SMN1; SMN2SIGMAR1L3MBTL1 | |
| SCHEMBL19010425 | 0.82 | ALDH1A1 (0.61) | ALDH1A1TDP1SMN1; SMN2SIGMAR1L3MBTL1 | |
| SCHEMBL2924557 | 0.81 | ALDH1A1 (0.70) | ALDH1A1TDP1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL14369163 | 0.75 | ALDH1A1 (0.52) | ALDH1A1TDP1SMN1; SMN2SIGMAR1L3MBTL1 | |
| SCHEMBL24282348 | 0.75 | ALDH1A1 (0.52) | ALDH1A1TDP1SMN1; SMN2SIGMAR1L3MBTL1 | |
| SCHEMBL15199216 | 0.73 | ALDH1A1 (0.59) | ALDH1A1TDP1SMN1; SMN2SIGMAR1L3MBTL1 | |
| SCHEMBL19022021 | 0.73 | SIGMAR1 (0.65) | ALDH1A1TDP1SMN1; SMN2SIGMAR1KMT2A | |
| SCHEMBL29315763 | 0.73 | KDM4E (0.51) | ALDH1A1TDP1SMN1; SMN2SIGMAR1KMT2A | |
| SCHEMBL26577967 | 0.73 | KDM4E (0.39) | ALDH1A1TDP1SMN1; SMN2SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019492-B1 | AMILORIDE-TYPE COMPOUNDS AS INHIBITORS IN EPITHELIAL SODIUM CHANNELS FOR THE TREATMENT OF DISEASES OF THE LUNGS AND AIRWAYS | BOEHRINGER INGELHEIM INT (DE) | 2017-09-06 | — | — | EP | disclosed |