Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1786624 | 0.86 | NPSR1 (0.56) | NPSR1LMNATSHRNPC1RAB9A | |
| SCHEMBL555280 | 0.82 | ATM (0.57) | ATMNPSR1LMNAPRMT5TSHR | |
| SCHEMBL1931814 | 0.77 | ATM (0.54) | ATMNPSR1LMNATSHRRAB9A | |
| SCHEMBL1932186 | 0.77 | PRMT5 (0.43) | ATMNPSR1LMNAPRMT5TSHR | |
| SCHEMBL1933716 | 0.71 | ROCK1 (0.51) | ATMNPSR1LMNATSHRNPC1 | |
| SCHEMBL1934226 | 0.71 | PDE4A (0.52) | ATMNPSR1LMNATSHRNPC1 | |
| SCHEMBL1932753 | 0.71 | NPSR1 (0.54) | ATMNPSR1LMNATSHRGAA | |
| SCHEMBL1933205 | 0.70 | PRMT5 (0.38) | ATMNPSR1PRMT5NPC1RAB9A | |
| SCHEMBL1933711 | 0.70 | CHRNA7 (0.42) | ATMNPSR1PRMT5NPC1RAB9A | |
| SCHEMBL434996 | 0.67 | NPSR1 (0.58) | NPSR1LMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011066168-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2011-06-03 | — | — | WO | disclosed |