Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | GFER | P55789 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19322175 | 0.86 | KDM4E (0.60) | NPC1RAB9AKDM4EGFERHPGD | |
| SCHEMBL17404514 | 0.84 | FASN (0.62) | NPC1RAB9AKDM4EGFERHPGD | |
| SCHEMBL13325928 | 0.81 | RAB9A (0.68) | NPC1RAB9AKDM4EGFERHPGD | |
| SCHEMBL25311377 | 0.81 | KDM4E (0.62) | NPC1RAB9AKDM4EGFERHPGD | |
| SCHEMBL19322151 | 0.80 | ALDH1A1 (0.55) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL3440320 | 0.80 | RAB9A (0.66) | NPC1RAB9AKDM4EGFERHPGD | |
| SCHEMBL3663283 | 0.79 | CLK1 (0.66) | NPC1RAB9AKDM4EGFERHPGD | |
| SCHEMBL3441125 | 0.79 | RAB9A (0.66) | NPC1RAB9AKDM4EGFERHPGD | |
| SCHEMBL2427998 | 0.79 | RAB9A (0.64) | NPC1RAB9AKDM4EGFERHPGD | |
| SCHEMBL19322173 | 0.78 | RAB9A (0.60) | NPC1RAB9AKDM4EGFERHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370373-B2 | Antitumor derivatives for differentiation therapy | THE CLEVELAND CLINIC FOUNDATION (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180194764-A1 | ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY | CLEVELAND CLINIC FOUND (US) | 2018-07-12 | — | — | US | disclosed |
| US-9926316-B2 | Antitumor derivatives for differentiation therapy | THE CLEVELAND CLINIC FOUNDATION (US) | 2018-03-27 | — | — | US | disclosed |
| US-20170253589-A1 | ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY | THE CLEVELAND CLINIC FOUNDATION | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194764-A1 | ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY | MYD88, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS | NPC1 3167/4885RAB9A 1723/4885KDM4E 1060/4885 |
| US-20170253589-A1 | ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY | MYD88, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS | NPC1 3167/4885RAB9A 1723/4885KDM4E 1060/4885 |
| US-10370373-B2 | Antitumor derivatives for differentiation therapy | MYD88, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS | NPC1 3167/4885RAB9A 1723/4885KDM4E 1060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.