Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.67 |
| ▸ | CYP11B2 | P19099 | 14/20 | 0.61 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1932877 | 1.00 | CYP19A1 (0.67) | CYP19A1CYP11B2CYP11B1KCNH2CYP17A1 | |
| SCHEMBL14769012 | 0.82 | CYP19A1 (0.43) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL2348591 | 0.81 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2CYP17A1 | |
| SCHEMBL17898239 | 0.81 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2CYP17A1 | |
| Hydrochloric Acid SCHEMBL9836543 | 0.80 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2CYP17A1 | |
| Fadrozole SCHEMBL25491 | 0.76 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| S-Fadrozole SCHEMBL13449014 | 0.76 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Dexfadrostat SCHEMBL685516 | 0.76 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Fadrozole SCHEMBL3295820 | 0.76 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Fadrozole SCHEMBL4143 | 0.75 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507234-B1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2014-03-12 | — | — | EP | disclosed |
| EP-2507234-B1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2014-03-12 | — | — | EP | disclosed |
| US-8575160-B2 | Imidazole derivatives as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2013-11-05 | — | — | US | disclosed |
| US-8575160-B2 | Imidazole derivatives as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2013-11-05 | — | — | US | disclosed |
| US-8575160-B2 | Imidazole derivatives as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2013-11-05 | — | — | US | disclosed |
| US-20130065893-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2013-03-14 | — | — | US | disclosed |
| US-20130065893-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2013-03-14 | — | — | US | disclosed |
| US-20130065893-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2013-03-14 | — | — | US | disclosed |
| EP-2507234-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | Novartis AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011064376-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2011-06-03 | — | — | WO | disclosed |
| WO-2011064376-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2011-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065893-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | CYP11B1, CYP21A2, CYP11B2 | CYP19A1 58/4885CYP11B2 3/4885CYP11B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.