Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1932877 | 0.82 | CYP19A1 (0.67) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL1932876 | 0.82 | CYP19A1 (0.67) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL24860259 | 0.72 | HSP90AA1 (0.33) | CYP19A1CYP11B2IDO1TDO2CYP3A4 | |
| SCHEMBL14769100 | 0.72 | CYP19A1 (0.73) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL2790501 | 0.70 | IDO1 (0.48) | CYP11B2IDO1TDO2CYP3A4 | |
| SCHEMBL741402 | 0.61 | CYP11B2 (0.43) | CYP19A1CYP11B2MEN1KMT2ACYP11B1 | |
| SCHEMBL18366270 | 0.61 | CHRM2 (0.47) | L3MBTL1KDM4ECYP3A4THRBTSHR | |
| SCHEMBL20646025 | 0.61 | CHRM2 (0.47) | L3MBTL1KDM4ECYP3A4THRBTSHR | |
| SCHEMBL13225803 | 0.61 | KDM4E (0.66) | L3MBTL1KDM4ECYP3A4THRBTSHR | |
| SCHEMBL11708369 | 0.61 | KDM4E (0.66) | L3MBTL1KDM4ECYP3A4THRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575160-B2 | Imidazole derivatives as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2013-11-05 | — | — | US | disclosed |
| US-20130065893-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065893-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | CYP11B1, CYP21A2, CYP11B2 | CYP19A1 58/4885L3MBTL1 4840/4885CYP11B2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.