Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.33 |
| ▸ | USP2 | O75604 | 7/20 | 0.33 |
| ▸ | CASP1 | P29466 | 7/20 | 0.33 |
| ▸ | CASP7 | P55210 | 7/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2314920 | 0.83 | DGAT1 (0.38) | ALOX15TDP1DGAT1CYP1A2CYP3A4 | |
| SCHEMBL1932973 | 0.82 | DGAT1 (0.39) | ALOX15TDP1DGAT1ALDH1A1HSD17B10 | |
| SCHEMBL2317159 | 0.79 | TDP1 (0.39) | ALOX15TDP1DGAT1ALDH1A1USP2 | |
| SCHEMBL4065268 | 0.74 | TDP1 (0.44) | ALOX15TDP1DGAT1ALDH1A1USP2 | |
| SCHEMBL1536819 | 0.73 | LCK (0.38) | CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL2320195 | 0.72 | ALOX15 (0.37) | ALOX15TDP1DGAT1ALDH1A1USP2 | |
| SCHEMBL1536984 | 0.72 | LCK (0.39) | CYP1A2CYP3A4CYP2C9USP2CASP1 | |
| SCHEMBL1536781 | 0.72 | LCK (0.39) | CYP1A2CYP3A4CYP2C9CYP2C19USP2 | |
| SCHEMBL2315378 | 0.71 | TDP1 (0.36) | ALOX15TDP1DGAT1ALDH1A1USP2 | |
| SCHEMBL2317903 | 0.71 | LCK (0.39) | CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506713-A1 | NOVEL TRICYCLIC COMPOUNDS | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068899-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |