Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331998 | 0.88 | CNR2 (0.38) | PIK3R1PIK3CAADAM17MMP2MMP13 | |
| SCHEMBL19331746 | 0.82 | JAK2 (0.41) | PIK3R1PIK3CAADAM17MMP2MMP13 | |
| SCHEMBL19331794 | 0.81 | PIK3R1 (0.36) | PIK3R1PIK3CAADAM17MMP2MMP13 | |
| SCHEMBL19331734 | 0.79 | HPGD (0.37) | PIK3R1PIK3CAADAM17MMP2MMP13 | |
| SCHEMBL5567244 | 0.78 | HDAC2 (0.39) | PIK3R1PIK3CAEPHX2HDAC2USP2 | |
| SCHEMBL5568440 | 0.78 | HDAC2 (0.37) | PIK3R1PIK3CAEPHX2HDAC2USP2 | |
| SCHEMBL1586974 | 0.72 | EPHX2 (0.43) | ADAM17MMP13MAPTEPHX2HDAC2 | |
| SCHEMBL24080972 | 0.72 | USP2 (0.42) | ADAM17MMP2MMP13MMP14HPGD | |
| SCHEMBL1684623 | 0.72 | EPHX2 (0.40) | ADAM17MMP13MAPTEPHX2HDAC2 | |
| SCHEMBL19331967 | 0.71 | HPGD (0.36) | PIK3R1PIK3CAADAM17MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156177-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |
| WO-2017156177-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |