Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.62 |
| ▸ | JAK3 | P52333 | 3/20 | 0.62 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PGK1 | P00558 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185388 | 0.84 | TTK (0.63) | JAK2JAK3CNR2ERN1UBE2N | |
| SCHEMBL1933198 | 0.81 | JAK2 (0.78) | JAK2JAK3CNR2ERN1UBE2N | |
| SCHEMBL2640445 | 0.77 | JAK2 (1.00) | JAK2JAK3TTK | |
| SCHEMBL7973589 | 0.77 | JAK2 (0.74) | JAK2JAK3TP53JAK1 | |
| SCHEMBL13536706 | 0.75 | JAK2 (0.64) | JAK2JAK3MAPTTP53JAK1 | |
| SCHEMBL13536674 | 0.75 | JAK2 (0.71) | JAK2JAK3TTKJAK1 | |
| SCHEMBL13536506 | 0.75 | JAK2 (0.71) | JAK2JAK3TP53JAK1 | |
| SCHEMBL2145664 | 0.75 | JAK2 (0.56) | JAK2JAK3TTKJAK1 | |
| SCHEMBL12507087 | 0.71 | TTK (0.63) | JAK2ERN1TTKCFD | |
| SCHEMBL1932419 | 0.70 | TTK (0.67) | JAK2JAK3TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507235-A1 | TRIAZOLOPYRIDINES | Bayer Intellectual Property GmbH (DE) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011063908-A1 | TRIAZOLOPYRIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-03 | — | — | WO | disclosed |