Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331004 | 1.00 | MEN1 (0.32) | MEN1KMT2ALMNAKDM4EHTT | |
| SCHEMBL19332733 | 1.00 | MEN1 (0.32) | MEN1KMT2ALMNAKDM4EHTT | |
| SCHEMBL19332734 | 1.00 | MEN1 (0.32) | MEN1KMT2ALMNAKDM4EHTT | |
| SCHEMBL19331001 | 1.00 | MEN1 (0.32) | MEN1KMT2ALMNAKDM4EHTT | |
| SCHEMBL19331303 | 0.86 | LMNA (0.40) | MEN1KMT2ALMNARAB9AALDH1A1 | |
| SCHEMBL19331299 | 0.86 | LMNA (0.40) | MEN1KMT2ALMNARAB9AALDH1A1 | |
| SCHEMBL19341958 | 0.85 | LMNA (0.33) | MEN1KMT2ALMNAKDM4EHTT | |
| SCHEMBL19332421 | 0.83 | LMNA (0.34) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL19332511 | 0.83 | HSD11B1 (0.31) | — | |
| SCHEMBL19332567 | 0.83 | ERN1 (0.32) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156181-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |