⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027928 | 0.71 | — | — | |
| SCHEMBL18508 | 0.71 | — | — | |
| SCHEMBL2869266 | 0.69 | — | — | |
| SCHEMBL6004069 | 0.69 | — | — | |
| SCHEMBL6912177 | 0.69 | — | — | |
| SCHEMBL9635137 | 0.68 | CYP2A6 (0.73) | — | |
| SCHEMBL1868904 | 0.67 | — | — | |
| Methane SCHEMBL21489530 | 0.67 | CYP2A6 (0.89) | — | |
| SCHEMBL21518322 | 0.67 | — | — | |
| SCHEMBL3138002 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507234-B1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2014-03-12 | — | — | EP | disclosed |
| US-8575160-B2 | Imidazole derivatives as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2013-11-05 | — | — | US | disclosed |
| US-20130065893-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2013-03-14 | — | — | US | disclosed |
| EP-2507234-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | Novartis AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011064376-A1 | IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2011-06-03 | — | — | WO | disclosed |