Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.83 |
| ▸ | LMNA | P02545 | 4/20 | 0.83 |
| ▸ | HPGD | P15428 | 4/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.83 |
| ▸ | TP53 | P04637 | 1/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13402123 | 0.91 | L3MBTL1 (1.00) | L3MBTL1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL19334306 | 0.71 | LIG1 (0.83) | L3MBTL1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL19334492 | 0.71 | LIG1 (0.62) | L3MBTL1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL8292619 | 0.67 | KDM1A (0.67) | L3MBTL1LMNASMN1; SMN2KMT2ATP53 | |
| SCHEMBL19334337 | 0.67 | KDM4E (0.84) | L3MBTL1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL19334395 | 0.64 | KDM4E (0.52) | LMNASMN1; SMN2KMT2AKDM4EMAPT | |
| SCHEMBL15457450 | 0.64 | MEN1 (0.77) | L3MBTL1LMNASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL19298155 | 0.63 | LIG1 (1.00) | L3MBTL1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL13401821 | 0.63 | LIG1 (0.75) | L3MBTL1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL13401789 | 0.63 | LIG1 (1.00) | L3MBTL1LMNAHPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |