Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934066 | 1.00 | BRD4 (0.33) | BRD4MEN1KMT2ANOS3NOS1 | |
| SCHEMBL1934068 | 1.00 | BRD4 (0.33) | BRD4MEN1KMT2ANOS3NOS1 | |
| SCHEMBL1934262 | 1.00 | BRD4 (0.33) | BRD4MEN1KMT2ANOS3NOS1 | |
| SCHEMBL1933577 | 1.00 | BRD4 (0.33) | BRD4MEN1KMT2ANOS3NOS1 | |
| SCHEMBL9754958 | 0.87 | NOS3 (0.36) | MEN1KMT2ANOS3NOS1NOS2 | |
| SCHEMBL12629173 | 0.87 | NOS3 (0.36) | MEN1KMT2ANOS3NOS1NOS2 | |
| SCHEMBL6437994 | 0.87 | NOS3 (0.36) | MEN1KMT2ANOS3NOS1NOS2 | |
| SCHEMBL6442259 | 0.87 | NOS3 (0.36) | MEN1KMT2ANOS3NOS1NOS2 | |
| SCHEMBL6438530 | 0.76 | NOS1 (0.39) | NOS3NOS1NOS2 | |
| SCHEMBL6440814 | 0.76 | NOS1 (0.39) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506716-A1 | NOVEL TRICYCLIC COMPOUNDS | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068881-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |