Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286520 | 0.79 | HPGD (0.55) | HPGDKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL5321421 | 0.66 | KDM4E (0.51) | HPGDKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL6733562 | 0.65 | CA1 (0.79) | KDM4EALDH1A1TDP1MAPTGAA | |
| SCHEMBL9151672 | 0.65 | CA1 (0.79) | KDM4EALDH1A1TDP1MAPTGAA | |
| SCHEMBL197522 | 0.65 | CA1 (0.79) | KDM4EALDH1A1TDP1MAPTGAA | |
| SCHEMBL28890215 | 0.62 | CA1 (0.73) | KDM4EALDH1A1TDP1MAPTGAA | |
| Iodide SCHEMBL28861996 | 0.62 | CA1 (0.73) | KDM4EALDH1A1TDP1MAPTGAA | |
| 1,4-Dimethoxybenzene SCHEMBL21802643 | 0.62 | CA1 (1.00) | KDM4EALDH1A1TDP1MAPTGAA | |
| 1,4-Dimethoxybenzene SCHEMBL8489 | 0.62 | CA1 (1.00) | KDM4EALDH1A1TDP1MAPTGAA | |
| SCHEMBL20370341 | 0.61 | NPC1 (0.50) | HPGDKDM4EALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297133-B1 | 1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS | FORUM PHARMACEUTICALS INC (US) | 2017-09-13 | — | — | EP | disclosed |