Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.65 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | GRK2 | P25098 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | GRK5 | P34947 | 1/20 | 0.52 |
| ▸ | GRK6 | P43250 | 1/20 | 0.52 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.52 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.52 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315834 | 0.86 | MMP13 (0.64) | MMP13SLC22A8ROCK1AURKAPRKCB | |
| SCHEMBL2491607 | 0.86 | MMP13 (0.64) | MMP13SLC22A8ROCK1AURKAPRKCB | |
| SCHEMBL29147374 | 0.86 | MMP13 (0.64) | MMP13SLC22A8MAPTROCK1AURKA | |
| SCHEMBL29065789 | 0.84 | GRK2 (0.65) | MMP13GRK2GRK5TRPA1TP53 | |
| SCHEMBL2317430 | 0.82 | SCD (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2317224 | 0.82 | MMP13 (0.59) | MMP13SLC22A8MAPTPOLBKDM4E | |
| SCHEMBL2494650 | 0.82 | MMP13 (0.68) | MMP13SLC22A8ROCK1AURKAPRKCB | |
| SCHEMBL2499849 | 0.81 | MMP13 (0.60) | MMP13SLC22A8ROCK1AURKAPRKCB | |
| SCHEMBL2494716 | 0.80 | MMP13 (0.64) | MMP13SLC22A8ROCK1HDAC3HDAC4 | |
| SCHEMBL5124722 | 0.80 | HDAC6 (0.62) | MMP13SLC22A8ROCK1GRK2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |