Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL28290540 | 0.96 | TSHR (0.50) | — | |
| Guanidine SCHEMBL4296464 | 0.96 | — | — | |
| Benzene SCHEMBL28326043 | 0.89 | TSHR (0.43) | — | |
| Guanidine SCHEMBL28137273 | 0.86 | — | — | |
| Isopropyl Alcohol SCHEMBL11151903 | 0.86 | TSHR (0.40) | — | |
| Guanidine SCHEMBL635186 | 0.86 | ALDH1A1 (0.40) | — | |
| Propanol SCHEMBL4327260 | 0.84 | — | — | |
| Acetamidine SCHEMBL27780039 | 0.84 | — | — | |
| Sulfuric Acid SCHEMBL27815548 | 0.83 | BLM (0.52) | — | |
| Butane SCHEMBL10941992 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551332-B1 | INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE | CEPHEID (US) | 2024-01-10 | — | — | EP | claimed |
| EP-3307885-B1 | INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE | CEPHEID (US) | 2020-10-21 | — | — | EP | claimed |
| CN-106146573-A | Leonurine metabolite and preparation method thereof | 复旦大学 | 2016-11-23 | — | — | CN | claimed |
| US-20100137188-A1 | FORMULATIONS COMPRISING CYCLIC COMPOUNDS | CAPSUGEL BELGIUM (BE) | 2010-06-03 | — | — | US | claimed |
| US-20100062050-A1 | MEANS AND METHODS OF ENHANCING DELIVERY TO BIOLOGICAL SYSTEMS | CAPSUGEL BELGIUM (BE) | 2010-03-11 | — | — | US | claimed |
| JP-2010504929-A | — | — | 2010-02-18 | — | — | JP | claimed |
| EP-2068936-A2 | MEANS AND METHODS OF ENHANCING DELIVERY TO BIOLOGICAL SYSTEMS | Botti, Paolo (CH) | 2009-06-17 | — | — | EP | claimed |
| EP-2068934-A2 | FORMULATIONS COMPRISING CYCLIC COMPOUNDS | Botti, Paolo (CH) | 2009-06-17 | — | — | EP | claimed |
| WO-2008037463-A2 | MEANS AND METHODS OF ENHANCING DELIVERY TO BIOLOGICAL SYSTEMS | BOTTI PAOLO (CH) | 2008-04-03 | — | — | WO | claimed |
| WO-2008037484-A2 | FORMULATIONS COMPRISING CYCLIC COMPOUNDS | BOTTI PAOLO (CH) | 2008-04-03 | — | — | WO | claimed |
| EP-1905454-A1 | Formulations comprising cyclic compounds | Botti, Paolo (CH) | 2008-04-02 | — | — | EP | claimed |
| US-20230349922-A1 | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer | UNIVERSITÉ DE STRASBOURG (FR) | 2023-11-02 | — | — | US | disclosed |
| EP-4196793-A1 | H2 BLOCKERS TARGETING LIVER MACROPHAGES FOR THE PREVENTION AND TREATMENT OF LIVER DISEASE AND CANCER | Université de Strasbourg (FR) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022034121-A1 | H2 BLOCKERS TARGETING LIVER MACROPHAGES FOR THE PREVENTION AND TREATMENT OF LIVER DISEASE AND CANCER | UNIVERSITÉ DE STRASBOURG (FR) | 2022-02-17 | — | — | WO | disclosed |
| EP-3565902-A1 | METHOD FOR DETECTING AND QUANTIFYING CIRCULATING DNA AND USES | CFID.Solutions (FR) | 2019-11-13 | — | — | EP | disclosed |
| US-5364616-A | Use of H-2 antagonists for treatment of gingivitis | THE PROCTER & GAMBLE COMPANY (US) | 1994-11-15 | — | — | US | disclosed |
| CN-1086824-A | Calcium channel blocking polypeptide from agelenopsis aperta | PFIZER (US) | 1994-05-18 | — | — | CN | disclosed |
| US-5294433-A | Dentistry | THE PROCTER & GAMBLE COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| CN-1082400-A | The purposes of H-2 antagonist for treating gingivitis | PROCTER & GAMBLE (US) | 1994-02-23 | — | — | CN | disclosed |
| WO-1993020815-A1 | USE OF H-2 ANTAGONISTS FOR TREATMENT OF GINGIVITIS | THE PROCTER & GAMBLE COMPANY (US) | 1993-10-28 | — | — | WO | disclosed |