Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL28290540 | 1.00 | TSHR (0.50) | — | |
| Guanidine SCHEMBL1933907 | 0.96 | — | — | |
| Acetamidine SCHEMBL27780039 | 0.88 | — | — | |
| Benzene SCHEMBL28326043 | 0.85 | TSHR (0.43) | — | |
| Guanidine SCHEMBL28137273 | 0.82 | — | — | |
| Isopropyl Alcohol SCHEMBL11151903 | 0.82 | TSHR (0.40) | — | |
| Guanidine SCHEMBL635186 | 0.82 | ALDH1A1 (0.40) | — | |
| Guanidine SCHEMBL28861357 | 0.80 | — | — | |
| Propanol SCHEMBL4327260 | 0.80 | — | — | |
| Butane SCHEMBL10941992 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113844152-A | Manufacturing method of antibacterial moisturizing pet urinal pad | 江苏中恒宠物用品股份有限公司 | 2021-12-28 | — | — | CN | claimed |
| US-20230392189-A1 | ISOLATION AND DETECTION OF DNA FROM PLASMA | JPMORGAN CHASE BANK, N.A. | 2023-12-07 | — | — | US | disclosed |
| US-11674168-B2 | Isolation and detection of DNA from plasma | EXACT SCIENCES CORPORATION (US) | 2023-06-13 | — | — | US | disclosed |
| EP-3998353-A1 | MULTIPLEX AMPLIFICATION DETECTION ASSAY AND ISOLATION AND DETECTION OF DNA FROM PLASMA | Exact Sciences Corporation (US) | 2022-05-18 | — | — | EP | disclosed |
| US-20220119862-A1 | Multiplex Amplification Detection Assay II | EXACT SCIENCES CORPORATION | 2022-04-21 | — | — | US | disclosed |
| CN-113844152-A | Manufacturing method of antibacterial moisturizing pet urinal pad | 江苏中恒宠物用品股份有限公司 | 2021-12-28 | — | — | CN | disclosed |
| US-11193168-B2 | Multiplex amplification detection assay II | EXACT SCIENCES DEVELOPMENT COMPANY, LLC (US) | 2021-12-07 | — | — | US | disclosed |
| US-20210079451-A1 | ISOLATION AND DETECTION OF DNA FROM PLASMA | JPMORGAN CHASE BANK, N.A. | 2021-03-18 | — | — | US | disclosed |
| US-10822638-B2 | Isolation and detection of DNA from plasma | EXACT SCIENCES DEVELOPMENT COMPANY, LLC (US) | 2020-11-03 | — | — | US | disclosed |
| US-20200291458-A1 | MULTIPLEX AMPLIFICATION DETECTION ASSAY | JPMORGAN CHASE BANK, N.A. | 2020-09-17 | — | — | US | disclosed |
| WO-2017075061-A1 | MULTIPLEX AMPLIFICATION DETECTION ASSAY AND ISOLATION AND DETECTION OF DNA FROM PLASMA | EXACT SCIENCES CORPORATION (US) | 2017-05-04 | — | — | WO | disclosed |
| US-20170121757-A1 | MULTIPLEX AMPLIFICATION DETECTION ASSAY | JPMORGAN CHASE BANK, N.A. | 2017-05-04 | — | — | US | disclosed |
| US-20170121704-A1 | ISOLATION AND DETECTION OF DNA FROM PLASMA | JPMORGAN CHASE BANK, N.A. | 2017-05-04 | — | — | US | disclosed |
| US-20090230302-A1 | Electron Transfer Dissociation for Biopolymer Sequence Analysis | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-09-17 | — | — | US | disclosed |
| US-20040138418-A1 | Epstein Barr virus induced genes | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2004-07-15 | — | — | US | disclosed |
| US-6699971-B2 | FOR THE DETECTION OF THE PRESENCE OF EPSTEIN BARR VIRUS | THE BRIGHAM & WOMEN'S HOSPITAL, INC. | 2004-03-02 | — | — | US | disclosed |
| US-6500926-B1 | ISOLATED POLYPEPTIDES OF GIVEN SEQUENCE; USE FOR DETECTION OF THE PRESENCE OF EPSTEIN BARR VIRUS | THE BRIGHAM & WOMEN'S HOSPITAL, INC. | 2002-12-31 | — | — | US | disclosed |
| US-20020040133-A1 | Epstein barr virus induced genes | BIRKENBACH MARK (US) | 2002-04-04 | — | — | US | disclosed |
| US-6043351-A | DNA SEGMENTS WHICH CODE FOR POLYPEPTIDES WITH SPECIFIC AMINO ACID SEQUENCES; FOR HYBRIDIZATION PROBES AND DIAGNOSTIC KITS TO DETECT VIRUS IN BIOLOGICAL SAMPLES | BRIGHAM AND WOMEN'S HOSPITAL (US) | 2000-03-28 | — | — | US | disclosed |
| US-5744301-A | DETECTING LEVEL OR SIZE OF EPSTEIN BARR VIRUS INDUCED NUCLEIC ACID OR PROTEIN IN MATERNAL SERUM SAMPLE, COMPARING WITH CONTROL | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1998-04-28 | — | — | US | disclosed |