Sugi Predict

Sugi Predict / Compounds / SCHEMBL19343933

SCHEMBL19343933

SCHEMBL19343933

CC(=O)Nc1ncnc2c1ccn2C1CCC(CN2CCCC23CCN(C)CC3)O1

nearest known ligand 0.51

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 9/20 0.51
▸ WDR77 Q9BQA1 8/20 0.51
▸ ACACB O00763 1/20 0.32
▸ PIP4K2A P48426 2/20 0.32
▸ PIK3CG P48736 2/20 0.32
▸ SIGMAR1 Q99720 8/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19344042 0.91 PRMT5 (0.49) PRMT5WDR77ACACBSIGMAR1
SCHEMBL23584831 0.87 PRMT5 (0.51) PRMT5WDR77
SCHEMBL23584679 0.84 PRMT5 (0.55) PRMT5WDR77
SCHEMBL19344168 0.84 PRMT5 (0.68) PRMT5WDR77
SCHEMBL19344223 0.83 PRMT5 (0.48) PRMT5WDR77
SCHEMBL23584861 0.81 PRMT5 (0.46) PRMT5WDR77
SCHEMBL19343915 0.81 PRMT5 (0.57) PRMT5WDR77
SCHEMBL19344204 0.80 PRMT5 (0.39) PRMT5WDR77
SCHEMBL19344219 0.80 PRMT5 (0.41) PRMT5WDR77SIGMAR1
SCHEMBL23584788 0.77 PRMT5 (0.54) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3426664-B1 SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2021-06-30 — — EP disclosed
WO-2017153186-A1 SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2017-09-14 — — WO disclosed
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