Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.30 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.30 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25948690 | 0.83 | HRH4 (0.45) | HRH4HRH3LMNADRD1PDE2A | |
| SCHEMBL23584542 | 0.83 | HRH4 (0.45) | HRH4HRH3LMNADRD1PDE2A | |
| SCHEMBL19343951 | 0.82 | HTR1A (0.41) | BCHEHTR1APDE2ASSTR1SSTR2 | |
| SCHEMBL22002160 | 0.82 | HTR1A (0.41) | BCHEHTR1APDE2ASSTR1SSTR2 | |
| SCHEMBL17106780 | 0.82 | HTR1A (0.41) | BCHEHTR1APDE2ASSTR1SSTR2 | |
| SCHEMBL29937697 | 0.82 | HTR1A (0.41) | BCHEHTR1APDE2ASSTR1SSTR2 | |
| SCHEMBL17106778 | 0.82 | HTR1A (0.41) | BCHEHTR1APDE2ASSTR1SSTR2 | |
| SCHEMBL22434962 | 0.76 | HSPA5 (0.32) | HTR1A | |
| SCHEMBL18666890 | 0.76 | HSPA5 (0.36) | HRH4HRH3LMNAHTR1ADRD1 | |
| SCHEMBL22569894 | 0.76 | HRH4 (0.34) | HRH4HRH3LMNAPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |