Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.33 |
| ▸ | CDK9 | P50750 | 8/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12363999 | 0.79 | PDE10A (0.61) | PDE10ACCNT1CDK9KCNN3KCNN1 | |
| SCHEMBL4102510 | 0.77 | PDE10A (0.43) | PDE10APRKAA1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL31023 | 0.76 | PDE10A (0.46) | PDE10APRKAA1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30603250 | 0.73 | DYRK1A (0.43) | PDE10ACCNT1CDK9CDK5MAPK14 | |
| SCHEMBL16828091 | 0.73 | PDE10A (0.43) | PDE10APRKAA1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL12364000 | 0.73 | PDE10A (0.43) | PDE10APRKAA1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7431490 | 0.72 | PRKAB2 (0.54) | PDE10APRKAA1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1071726 | 0.70 | PDE10A (0.37) | PDE10APRKAA1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30443263 | 0.70 | CCR1 (0.47) | PDE10AKCNN3KDRMAPK14CDK2 | |
| SCHEMBL23933214 | 0.70 | CDK7 (0.49) | PDE10APRKAA1PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518931-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-08-27 | — | — | US | disclosed |
| EP-2509602-A1 | PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS | Cylene Pharmaceuticals, Inc. (US) | 2012-10-17 | — | — | EP | disclosed |
| US-20110190264-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2011-08-04 | — | — | US | disclosed |
| WO-2011068667-A1 | PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190264-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | ROS1, IGF1R, INSR | PDE10A 2751/4885PRKAA1 340/4885PRKAB2 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.