Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688048 | 0.96 | CYP2C19 (0.42) | CYP2C19FFAR3 | |
| SCHEMBL11381914 | 0.78 | CYP2C19 (0.55) | CYP2C19MME | |
| SCHEMBL9687604 | 0.78 | CYP2C19 (0.41) | CYP2C19FFAR3 | |
| SCHEMBL9688857 | 0.76 | CYP2C19 (0.39) | CYP2C19 | |
| SCHEMBL9686990 | 0.75 | CYP2C19 (0.38) | CYP2C19MME | |
| SCHEMBL9687031 | 0.75 | CYP4F2 (0.45) | CYP4F2CYP4A11 | |
| SCHEMBL6119673 | 0.74 | CYP2C19 (0.50) | CYP2C19MME | |
| SCHEMBL14808862 | 0.72 | CYP2C19 (0.54) | CYP2C19MME | |
| SCHEMBL11377781 | 0.72 | CYP2C19 (0.54) | CYP2C19MME | |
| SCHEMBL17791681 | 0.70 | CYP2C19 (0.56) | CYP2C19MMEFFAR3CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331541-A1 | INDOLIZINE INHIBITORS OF LEUKOTRIENE PRODUCTION | Boehringer Ingelheim International GmbH (DE) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010027762-A1 | INDOLIZINE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |