Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 10/20 | 0.48 |
| ▸ | CTSL | P07711 | 7/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800362 | 0.97 | MAPT (0.57) | SYKMAPTCTSSCTSLCTSB | |
| SCHEMBL29458707 | 0.93 | MAPT (0.62) | SYKMAPTCTSSL3MBTL1KLK7 | |
| SCHEMBL13430765 | 0.84 | MAPT (0.54) | SYKMAPTCTSSCTSLCTSB | |
| SCHEMBL5707671 | 0.84 | MAPT (0.60) | SYKMAPTL3MBTL1POLBMAPK1 | |
| SCHEMBL19345774 | 0.84 | MAPT (0.60) | SYKMAPTL3MBTL1POLBMAPK1 | |
| SCHEMBL5114952 | 0.84 | MAPT (0.60) | SYKMAPTCTSSCTSLCTSB | |
| SCHEMBL29458852 | 0.83 | SYK (0.58) | SYKMAPTCTSSCTSLCTSB | |
| SCHEMBL8006799 | 0.83 | CTSS (0.64) | CTSSCTSLCTSBCTSK | |
| SCHEMBL3881957 | 0.83 | MAPT (0.59) | SYKMAPTL3MBTL1POLBMAPK1 | |
| SCHEMBL16789691 | 0.82 | MAPT (0.63) | SYKMAPTL3MBTL1KLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156071-A1 | CYCLIC KETO-AMIDE COMPOUNDS AS CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF | BLADE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |